This article has been cited by other articles in PMC. Abstract Mood disorders are a major public health problem and are associated with considerable burden of disease, suicides, physical comorbidities, high economic costs, and poor quality of life. Complementary and alternative medicine CAM has been used either alone or in combination with conventional therapies in patients with mood disorders.
Clinical trials with double-blind, active controlled design Toups et al. Data from initial and six-month surveys Open in a separate window ADs: In a large study designed to discover biomarkers and genotypes predictive of clinical outcome in MDD patients, Kloiber et al.
Various antidepressants were administered at the discretion of the attending physician. The response rate on the HAMD after 5 weeks was The authors reported that reduced improvement during antidepressant treatment in high-BMI patients was accompanied by smaller improvements in attention and hypothalamic-pituitary-adrenal HPA axis dysregulation compared with normal-BMI patients.
Poor treatment outcome in obese patients with depression was also previously reported in a meta-analysis. The results of the overweight and obese groups were not significantly different from each other. Of the patients included in the study population, Comparing these two groups of patients, non-remitters had a higher mean BMI Preliminary results obtained by our group unpublished also supported the long-term association of treatment-resistant depression TRD and baseline obesity.
In that study, we analyzed data from a nationwide prospective study of Korean patients with depressive disorders. For 52 weeks, the subjects were treated with various antidepressants according to the decision of the attending clinician.
However, not all studies support a negative effect of body weight on antidepressant responses. The prevalence of central obesity was not significantly different between TRD These results were not changed after adjusting for sex and age. The odds ratio of treatment resistance for high BMI vs.
The authors did not find any differences in antidepressant treatment outcomes across the BMI classes. The frequency, intensity, and burden of side effects were also not significantly different across groups in week 12, after adjustment.
In week 28, there were no differences in depression outcome or functional measures among groups.
The prevalence of abdominal obesity was Rather, significant predictors of depression chronicity were elevated: These results indicated that a certain degree of inflammatory and metabolic dysregulation, but not abdominal obesity, could worsen the course of depression due to a reduced antidepressant treatment response.
Atypical Depressive Symptoms A general consensus is that clinical heterogeneity complicates efforts to identify the biological, genetic, and environmental underpinnings of depression [ 24 ].
Especially, the atypical subtype is thought to contribute to the variability in associations with biological measures.role of interventions in preventing depressive disorders in high-risk groups. Several new directions for future research on the prevention of depression in high-risk groups were outlined.
While the literature relating to the technical process of heart rate variability and aspects of depressive disorders has been reviewed in the past, research relating to both depressive and bipolar disorders has not been comprehensively reviewed.
A review of the literature was conducted to explore the various ways that anxious depression is currently defined. Data from the Munich Follow-Up Study showed that co-morbidity of anxiety and depressive disorders based on DSM-III criteria was % in an epidemiologic sample and % in a clinical setting.
7 Another study of co-morbid. lar disorders, depressive disorders, anxiety disorders and schizophrenia (Alvares etal., ; Gorman and Sloan, This review examines the current literature which explores the associations of the ANS with both major depressive dis-A literature review of heart.
Literature Review Executive Summary: Emotional concerns in the workplace are a considerable loss to employee’s health and welfare. They slow down the performance of employee and so they are harmful to the organisational well-being as well. Depression and Pain Comorbidity A Literature Review.
, using the combined search terms depression or depressive disorders and pain. Articles were also identified by a manual search of bibliographies from all retrieved articles.
Some studies 35, and a literature review by Linton have suggested that depression has a greater.